The DYT6 Dystonia Protein THAP1 Regulates Myelination Within The Oligodendrocyte Lineage

The childhood-onset motor disorder DYT6 dystonia is caused by loss-of-function mutations in the transcription factor THAP1, but the neurodevelopmental processes in which THAP1 participates are unknown. We find that THAP1 is essential for the timing of myelination initiation during CNS maturation. Co...

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Udgivet i:Dev Cell
Main Authors: Yellajoshyula, Dhananjay, Liang, Chun-Chi, Pappas, Samuel S., Penati, Silvia, Yang, Angela, Mecano, Rodan, Kumaran, Ravindran, Jou, Stephanie, Cookson, Mark R., Dauer, William T.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847273/
https://ncbi.nlm.nih.gov/pubmed/28697333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.06.009
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