Cinacalcet corrects hypercalcemia in mice with an inactivating Gα(11) mutation

Loss-of-function mutations of GNA11, which encodes G-protein subunit α(11) (Gα(11)), a signaling partner for the calcium-sensing receptor (CaSR), result in familial hypocalciuric hypercalcemia type 2 (FHH2). FHH2 is characterized by hypercalcemia, inappropriately normal or raised parathyroid hormone...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Howles, Sarah A., Hannan, Fadil M., Gorvin, Caroline M., Piret, Sian E., Paudyal, Anju, Stewart, Michelle, Hough, Tertius A., Nesbit, M. Andrew, Wells, Sara, Brown, Stephen D.M., Cox, Roger D., Thakker, Rajesh V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846897/
https://ncbi.nlm.nih.gov/pubmed/29046478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96540
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