Cinacalcet corrects hypercalcemia in mice with an inactivating Gα(11) mutation

Loss-of-function mutations of GNA11, which encodes G-protein subunit α(11) (Gα(11)), a signaling partner for the calcium-sensing receptor (CaSR), result in familial hypocalciuric hypercalcemia type 2 (FHH2). FHH2 is characterized by hypercalcemia, inappropriately normal or raised parathyroid hormone...

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Enregistré dans:
Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Howles, Sarah A., Hannan, Fadil M., Gorvin, Caroline M., Piret, Sian E., Paudyal, Anju, Stewart, Michelle, Hough, Tertius A., Nesbit, M. Andrew, Wells, Sara, Brown, Stephen D.M., Cox, Roger D., Thakker, Rajesh V.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846897/
https://ncbi.nlm.nih.gov/pubmed/29046478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96540
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