Microenvironment-driven resistance to B-Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts

The incidence of malignant melanoma is rapidly increasing and current medicine is offering only limited options for treatment of the advanced disease. For B-Raf mutated melanomas, treatment with mutation-specific drug inhibitors may be used. Unfortunately, tumors frequently acquire resistance to the...

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Bibliographic Details
Published in:Int J Mol Med
Main Authors: Kodet, Ondřej, Dvořánková, Barbora, Bendlová, Běla, Sýkorová, Vlasta, Krajsová, Ivana, Štork, Jiří, Kučera, Jan, Szabo, Pavol, Strnad, Hynek, Kolář, Michal, Vlček, Čestmír, Smetana, Karel, Lacina, Lukáš
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2018
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846633/
https://ncbi.nlm.nih.gov/pubmed/29393387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3448
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