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A negative feedback regulation of MTORC1 activity by the lysosomal Ca(2+) channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism

Macroautophagy/autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. The lysosome plays an essential role in autophagy regulation. For example, the activity of MTORC1, a master regulator of autophagy, is regulated by nutrients within the lys...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Sun, Xue, Yang, Yiming, Zhong, Xi Zoë, Cao, Qi, Zhu, Xin-Hong, Zhu, Xiaojuan, Dong, Xian-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846559/
https://ncbi.nlm.nih.gov/pubmed/29460684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1389822
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