Pharmacogenomic and Pharmacokinetic Determinants of Erlotinib Toxicity

PURPOSE: To assess the pharmacogenomic and pharmacokinetic determinants of skin rash and diarrhea, the two primary dose-limiting toxicities of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib. PATIENTS AND METHODS: A prospective clinical study of 80 patients with non–s...

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Pubblicato in:J Clin Oncol
Autori principali: Rudin, Charles M., Liu, Wanqing, Desai, Apurva, Karrison, Theodore, Jiang, Xuemin, Janisch, Linda, Das, Soma, Ramirez, Jacqueline, Poonkuzhali, Balasubramanian, Schuetz, Erin, Fackenthal, Donna Lee, Chen, Peixian, Armstrong, Deborah K., Brahmer, Julie R., Fleming, Gini F., Vokes, Everett E., Carducci, Michael A., Ratain, Mark J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846189/
https://ncbi.nlm.nih.gov/pubmed/18309947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2007.13.1128
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