Pharmacogenomic and Pharmacokinetic Determinants of Erlotinib Toxicity

PURPOSE: To assess the pharmacogenomic and pharmacokinetic determinants of skin rash and diarrhea, the two primary dose-limiting toxicities of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib. PATIENTS AND METHODS: A prospective clinical study of 80 patients with non–s...

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Publicado no:J Clin Oncol
Main Authors: Rudin, Charles M., Liu, Wanqing, Desai, Apurva, Karrison, Theodore, Jiang, Xuemin, Janisch, Linda, Das, Soma, Ramirez, Jacqueline, Poonkuzhali, Balasubramanian, Schuetz, Erin, Fackenthal, Donna Lee, Chen, Peixian, Armstrong, Deborah K., Brahmer, Julie R., Fleming, Gini F., Vokes, Everett E., Carducci, Michael A., Ratain, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846189/
https://ncbi.nlm.nih.gov/pubmed/18309947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2007.13.1128
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