Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism

Altered glycolytic flux in cancer cells (the “Warburg effect”) causes their proliferation to rely upon elevated glutamine metabolism (“glutamine addiction”). This requirement is met by the overexpression of glutaminase C (GAC), which catalyzes the first step in glutamine metabolism and therefore rep...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Huang, Qingqiu, Stalnecker, Clint, Zhang, Chengliang, McDermott, Lee A., Iyer, Prema, O'Neill, Jason, Reimer, Shawn, Cerione, Richard A., Katt, William P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846160/
https://ncbi.nlm.nih.gov/pubmed/29317493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.810101
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