LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase–dependent proteolysis of the stem-cell protein SOX2

The pluripotency-controlling stem-cell protein SRY-box 2 (SOX2) plays a pivotal role in maintaining the self-renewal and pluripotency of embryonic stem cells and also of teratocarcinoma or embryonic carcinoma cells. SOX2 is monomethylated at lysine 119 (Lys-119) in mouse embryonic stem cells by the...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Zhang, Chunxiao, Hoang, Nam, Leng, Feng, Saxena, Lovely, Lee, Logan, Alejo, Salvador, Qi, Dandan, Khal, Anthony, Sun, Hong, Lu, Fei, Zhang, Hui
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846134/
https://ncbi.nlm.nih.gov/pubmed/29358331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000342
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items