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Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity
[Image: see text] We demonstrate that lipidomics coupled with molecular dynamics reveal unique phospholipase A(2) specificity toward membrane phospholipid substrates. We discovered unexpected headgroup and acyl-chain specificity for three major human phospholipases A(2). The differences between each...
Gardado en:
| Publicado en: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical
Society
2018
|
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5846079/ https://ncbi.nlm.nih.gov/pubmed/29342349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b12045 |
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