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Membranes serve as allosteric activators of phospholipase A(2), enabling it to extract, bind, and hydrolyze phospholipid substrates

Defining the molecular details and consequences of the association of water-soluble proteins with membranes is fundamental to understanding protein–lipid interactions and membrane functioning. Phospholipase A(2) (PLA(2)) enzymes, which catalyze the hydrolysis of phospholipid substrates that compose...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Mouchlis, Varnavas D., Bucher, Denis, McCammon, J. Andrew, Dennis, Edward A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330758/
https://ncbi.nlm.nih.gov/pubmed/25624474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424651112
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