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Specific transcriptional enhancement of inducible nitric oxide synthase by targeted promoter demethylation

The ability to specifically reactivate epigenetically silenced genes would have great utility in experimental studies and potential therapeutic value. Here, we describe the specific targeting of thymidine DNA glycosylase (TDG), an enzyme involved in the mechanism of methylcytosine demethylation, to...

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Vydáno v:Epigenetics
Hlavní autoři: Gregory, David J, Zhang, Yiming, Kobzik, Lester, Fedulov, Alexey V
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845820/
https://ncbi.nlm.nih.gov/pubmed/24008769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.26267
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