Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

In the hepatitis B virus (HBV)-related hepatocellular carcinoma tumor microenvironment (TME), monocytes reportedly impede natural T cell functions via PD-L1/PD-1 signaling. However, it remains unclear if T cell receptor-redirected T cells (TCR T cells) are similarly inhibited. Hence, we developed a...

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Bibliografski detalji
Izdano u:Front Immunol
Glavni autori: Lee, Sharon Wei Ling, Adriani, Giulia, Ceccarello, Erica, Pavesi, Andrea, Tan, Anthony Tanoto, Bertoletti, Antonio, Kamm, Roger Dale, Wong, Siew Cheng
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Immunology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845585/
https://ncbi.nlm.nih.gov/pubmed/29559973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00416
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