A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors

The tumor microenvironment imposes physical and functional constraints on the antitumor efficacy of adoptive T cell immunotherapy. Preclinical testing of different T cell preparations can help in the selection of efficient immune therapies, but in vivo models are expensive and cumbersome to develop,...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Pavesi, Andrea, Tan, Anthony T., Koh, Sarene, Chia, Adeline, Colombo, Marta, Antonecchia, Emanuele, Miccolis, Carlo, Ceccarello, Erica, Adriani, Giulia, Raimondi, Manuela T., Kamm, Roger D., Bertoletti, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472441/
https://ncbi.nlm.nih.gov/pubmed/28614795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89762
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