Dendritic cell–targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation

Dendritic cell (DC) activation and antigen presentation are critical for efficient priming of T cell responses. Here, we study how lentiviral vectors (LVs) deliver antigen and activate DCs to generate T cell immunization in vivo. We report that antigenic proteins delivered in vector particles via ps...

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Vydáno v:Sci Immunol
Hlavní autoři: Kim, Jocelyn T., Liu, Yarong, Kulkarni, Rajan P., Lee, Kevin K., Dai, Bingbing, Lovely, Geoffrey, Ouyang, Yong, Wang, Pin, Yang, Lili, Baltimore, David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845465/
https://ncbi.nlm.nih.gov/pubmed/28733470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aal1329
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