Azoramide, a novel regulator, favors adipogenesis against osteogenesis through inhibiting the GLP-1 receptor-PKA-β-catenin pathway

BACKGROUND: The reciprocal fate decision of mesenchymal stem cells (MSCs) to either bone or adipocytes is determined by Wnt-related signaling and the glucagon-like peptide-1 receptor (GLP-1R). Azoramide, an ER stress alleviator, was reported to have an antidiabetic effect. In this study, we investig...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Ruan, Banjun, Zhu, Zheng, Yan, Zhao, Yang, Wei, Zhai, Dongsheng, Wang, Li, Ye, Zichen, Lu, Huanyu, Xiang, An, Liang, Jingwei, Jiang, Yinghao, Xu, Chengming, Wang, Zhenyu, Wei, Ming, Lei, Xiaoying, Cao, Xiaorui, Lu, Zifan
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845182/
https://ncbi.nlm.nih.gov/pubmed/29523188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-018-0771-y
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