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Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures

BACKGROUND: To understand the responses of the dental pulp to hypoxia is of high relevance for regenerative endodontics and dental traumatology. Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the production of sclerostin (SOST) and dickkopf-1 (DKK...

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Pubblicato in:BMC Oral Health
Autori principali: Janjić, Klara, Cvikl, Barbara, Kurzmann, Christoph, Moritz, Andreas, Agis, Hermann
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845180/
https://ncbi.nlm.nih.gov/pubmed/29523112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12903-018-0492-8
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