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Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures

BACKGROUND: To understand the responses of the dental pulp to hypoxia is of high relevance for regenerative endodontics and dental traumatology. Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the production of sclerostin (SOST) and dickkopf-1 (DKK...

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Detalhes bibliográficos
Publicado no:BMC Oral Health
Main Authors: Janjić, Klara, Cvikl, Barbara, Kurzmann, Christoph, Moritz, Andreas, Agis, Hermann
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845180/
https://ncbi.nlm.nih.gov/pubmed/29523112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12903-018-0492-8
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