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Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures

BACKGROUND: To understand the responses of the dental pulp to hypoxia is of high relevance for regenerative endodontics and dental traumatology. Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the production of sclerostin (SOST) and dickkopf-1 (DKK...

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Publicat a:BMC Oral Health
Autors principals: Janjić, Klara, Cvikl, Barbara, Kurzmann, Christoph, Moritz, Andreas, Agis, Hermann
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845180/
https://ncbi.nlm.nih.gov/pubmed/29523112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12903-018-0492-8
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