CDK6 inhibits white to beige fat transition by suppressing RUNX1

Whereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige adipose tissue has beneficial metabolic effects. Here we show that CDK6 regulates beige adipocyte formation. We demonstrate that mice lacking the CDK6 protein or its kinase domain (K43M) exhibit...

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Publié dans:Nat Commun
Auteurs principaux: Hou, Xiaoli, Zhang, Yongzhao, Li, Wei, Hu, Alexander J., Luo, Chi, Zhou, Wenhui, Hu, Jamie K., Daniele, Stefano G., Wang, Jinfeng, Sheng, Jinghao, Fan, Yongsheng, Greenberg, Andrew S., Farmer, Stephen R., Hu, Miaofen G.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845007/
https://ncbi.nlm.nih.gov/pubmed/29523786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03451-1
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