CDK6 inhibits white to beige fat transition by suppressing RUNX1

Whereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige adipose tissue has beneficial metabolic effects. Here we show that CDK6 regulates beige adipocyte formation. We demonstrate that mice lacking the CDK6 protein or its kinase domain (K43M) exhibit...

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I publikationen:Nat Commun
Huvudupphovsmän: Hou, Xiaoli, Zhang, Yongzhao, Li, Wei, Hu, Alexander J., Luo, Chi, Zhou, Wenhui, Hu, Jamie K., Daniele, Stefano G., Wang, Jinfeng, Sheng, Jinghao, Fan, Yongsheng, Greenberg, Andrew S., Farmer, Stephen R., Hu, Miaofen G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845007/
https://ncbi.nlm.nih.gov/pubmed/29523786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03451-1
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