Phagocytosis depends on TRPV2-mediated calcium influx and requires TRPV2 in lipids rafts: alteration in macrophages from patients with cystic fibrosis

Whereas many phagocytosis steps involve ionic fluxes, the underlying ion channels remain poorly defined. As reported in mice, the calcium conducting TRPV2 channel impacts the phagocytic process. Macrophage phagocytosis is critical for defense against pathogens. In cystic fibrosis (CF), macrophages h...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lévêque, Manuella, Penna, Aubin, Le Trionnaire, Sophie, Belleguic, Chantal, Desrues, Benoît, Brinchault, Graziella, Jouneau, Stéphane, Lagadic-Gossmann, Dominique, Martin-Chouly, Corinne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844937/
https://ncbi.nlm.nih.gov/pubmed/29523858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22558-5
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