The Mirn23a and Mirn23b MicroRNA Clusters are Necessary for Proper Hematopoietic Progenitor Cell Production and Differentiation

Mice deficient for microRNA (miRNA) cluster mirn23a exhibit increased B lymphopoiesis at the expense of myelopoiesis while hematopoietic stem and progenitor (HSPC) populations are unchanged. Mammals possess a paralogous mirn23b gene that can give rise to 3 mature miRNAs (miRs -23b, 24-1, and -27b) t...

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Publicat a:Exp Hematol
Autors principals: Kurkewich, Jeffrey L., Boucher, Austin, Klopfenstein, Nathan, Baskar, Ramdas, Kapur, Reuben, Dahl, Richard
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844848/
https://ncbi.nlm.nih.gov/pubmed/29288704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2017.12.007
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