The ERβ4 variant induces transformation of the normal breast mammary epithelial cell line MCF-10A; the ERβ variants ERβ2 and ERβ5 increase aggressiveness of TNBC by regulation of hypoxic signaling

Triple negative breast cancer (TNBC) still remains a challenge to treat in the clinic due to a lack of good targets for treatment. Although TNBC lacks expression of ERα, the expression of ERβ and its variants are detected quite frequently in this cancer type and can represent an avenue for treatment...

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Udgivet i:Oncotarget
Main Authors: Faria, Michelle, Karami, Samaneh, Granados-Principal, Sergio, Dey, Prasenjit, Verma, Akanksha, Choi, Dong S., Elemento, Olivier, Bawa-Khalfe, Tasneem, Chang, Jenny C., Strom, Anders M., Gustafsson, Jan-Åke
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844739/
https://ncbi.nlm.nih.gov/pubmed/29552303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24134
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