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The cohort multiple randomized controlled trial design was found to be highly susceptible to low statistical power and internal validity biases

OBJECTIVES: The “cohort multiple randomized controlled trial” (cmRCT) is a recent innovation by which novel interventions are trialed within large longitudinal cohorts of patients to gain efficiencies and align trials more closely to standard clinical practice. The use of cmRCTs is outpacing its met...

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Detalhes bibliográficos
Publicado no:J Clin Epidemiol
Main Authors: Reeves, David, Howells, Kelly, Sidaway, Mark, Blakemore, Amy, Hann, Mark, Panagioti, Maria, Bower, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844670/
https://ncbi.nlm.nih.gov/pubmed/29277558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jclinepi.2017.12.008
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