Yeast-based assays for characterization of the functional effects of single nucleotide polymorphisms in human DNA repair genes

DNA repair mechanisms maintain genomic integrity upon exposure to various types of DNA damage, which cause either single- or double-strand breaks in the DNA. Here, we propose a strategy for the functional study of single nucleotide polymorphisms (SNPs) in the human DNA repair genes XPD/ERCC2, RAD18,...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kim, Changshin, Yang, Jinmo, Jeong, Su-Hyun, Kim, Hayoung, Park, Geun-hee, Shin, Hwa Beom, Ro, MyungJa, Kim, Kyoung-Yeon, Park, YoungJoon, Kim, Keun Pil, Kwack, KyuBum
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844570/
https://ncbi.nlm.nih.gov/pubmed/29522548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193823
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