Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA

BACKGROUND: Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD(+) biosynthesis from nicotinamide, exhibit anticancer effects in preclinical models. However, continuous exposure to NAMPT inhibitors, such as FK866, can induce acquired resistance. METHODS: We...

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Veröffentlicht in:Cancer Metab
Hauptverfasser: Thongon, Natthakan, Zucal, Chiara, D’Agostino, Vito Giuseppe, Tebaldi, Toma, Ravera, Silvia, Zamporlini, Federica, Piacente, Francesco, Moschoi, Ruxanda, Raffaelli, Nadia, Quattrone, Alessandro, Nencioni, Alessio, Peyron, Jean-Francois, Provenzani, Alessandro
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5844108/
https://ncbi.nlm.nih.gov/pubmed/29541451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-018-0174-7
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