Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling

Sorafenib, a small inhibitor of tyrosine protein kinases, is currently the standard chemotherapy drug for the treatment of advanced hepatocellular carcinoma (HCC). Although sorafenib improves the survival of HCC patients, its efficacy is not optimal and requires further improvement. Capsaicin, the m...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Zhang, Su-shan, Ni, Yu-hao, Zhao, Chen-ru, Qiao, Zhen, Yu, Hong-xia, Wang, Lu-yao, Sun, Jin-yan, Du, Chen, Zhang, Jia-hao, Dong, Li-ying, Wang, KeWei, Gao, Jian-jun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843835/
https://ncbi.nlm.nih.gov/pubmed/29188798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.156
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