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The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
Lipopolysaccharide (LPS) of Gram-negative bacteria can elicit a strong immune response. Although extracellular LPS is sensed by TLR4 at the cell surface and triggers a transcriptional response, cytosolic LPS binds and activates non-canonical inflammasome caspases, resulting in pyroptotic cell death,...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5843631/ https://ncbi.nlm.nih.gov/pubmed/29520027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03409-3 |
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