The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

Lipopolysaccharide (LPS) of Gram-negative bacteria can elicit a strong immune response. Although extracellular LPS is sensed by TLR4 at the cell surface and triggers a transcriptional response, cytosolic LPS binds and activates non-canonical inflammasome caspases, resulting in pyroptotic cell death,...

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Pubblicato in:Nat Commun
Autori principali: Chu, Lan H., Indramohan, Mohanalaxmi, Ratsimandresy, Rojo A., Gangopadhyay, Anu, Morris, Emily P., Monack, Denise M., Dorfleutner, Andrea, Stehlik, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843631/
https://ncbi.nlm.nih.gov/pubmed/29520027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03409-3
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