Cabozantinib Affects Osteosarcoma Growth Through A Direct Effect On Tumor Cells and Modifications In Bone Microenvironment

Osteosarcoma (OS) is the most common primary malignant tumor of the bone. Due to its high heterogeneity and to survival signals from bone microenvironment, OS can resist to standard treatments, therefore novel therapies are needed. c-MET oncogene, a tyrosine-kinase receptor, plays a crucial role in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Fioramonti, M., Fausti, V., Pantano, F., Iuliani, M., Ribelli, G., Lotti, F., Pignochino, Y., Grignani, G., Santini, D., Tonini, G., Vincenzi, B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843583/
https://ncbi.nlm.nih.gov/pubmed/29520051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22469-5
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