Cabozantinib Affects Osteosarcoma Growth Through A Direct Effect On Tumor Cells and Modifications In Bone Microenvironment

Osteosarcoma (OS) is the most common primary malignant tumor of the bone. Due to its high heterogeneity and to survival signals from bone microenvironment, OS can resist to standard treatments, therefore novel therapies are needed. c-MET oncogene, a tyrosine-kinase receptor, plays a crucial role in...

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Udgivet i:Sci Rep
Main Authors: Fioramonti, M., Fausti, V., Pantano, F., Iuliani, M., Ribelli, G., Lotti, F., Pignochino, Y., Grignani, G., Santini, D., Tonini, G., Vincenzi, B.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843583/
https://ncbi.nlm.nih.gov/pubmed/29520051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22469-5
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