LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer

Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are characterized by genomic rearrangements and point mutations in the proto-oncogene RET. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a suppressor of various receptor tyrosine kinases, including RET. LRIG1...

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Detalhes bibliográficos
Publicado no:Int J Oncol
Main Authors: Lindquist, David, Alsina, Fernando C., Herdenberg, Carl, Larsson, Catharina, Höppener, Jo, Wang, Na, Paratcha, Gustavo, Tarján, Miklós, Tot, Tibor, Henriksson, Roger, Hedman, Håkan
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843404/
https://ncbi.nlm.nih.gov/pubmed/29436694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2018.4273
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