Expression of PD-1 and Tim-3 markers of T-cell exhaustion is associated with CD4 dynamics during the course of untreated and treated HIV infection

INTRODUCTION: T-cell exhaustion has been involved in the pathogenesis of HIV infection. We have longitudinally analyzed PD1 and Tim3 surrogate markers of T-cells exhaustion, in parallel with other markers of HIV progression, and its potential association with CD4 changes in treated and untreated inf...

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Bibliographic Details
Published in:PLoS One
Main Authors: Rallón, Norma, García, Marcial, García-Samaniego, Javier, Cabello, Alfonso, Álvarez, Beatriz, Restrepo, Clara, Nistal, Sara, Górgolas, Miguel, Benito, José M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843247/
https://ncbi.nlm.nih.gov/pubmed/29518102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193829
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