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Icotinib hydrochloride enhances chemo- and radiosensitivity by inhibiting EGFR signaling and attenuating RAD51 expression and function in Hela S3 cells

BACKGROUND: Radiotherapy and cisplatin-based chemotherapy are currently considered as standard treatments employed for advanced cervical cancer (CC). However, patients with local recurrence or distant metastasis continue to have poor outcomes. EGFR overexpression correlated with chemo/radioresistanc...

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Publicat a:Onco Targets Ther
Autors principals: Wang, Xuanxuan, Gu, Yanjun, Liu, Hai, Shi, Liming, Sun, Xiaonan
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843137/
https://ncbi.nlm.nih.gov/pubmed/29551903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S152613
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