Toxicologic/Transport Properties of NCS-382, a γ-Hydroxybutyrate (GHB) Receptor Ligand, in Neuronal and Epithelial Cells: Therapeutic Implications for SSADH Deficiency, a GABA Metabolic Disorder

We report the in vitro assessment of pharmacotoxicity for the high-affinity GHB receptor ligand, NCS-382, using neuronal stem cells derived from mice with a targeted deletion of the aldehyde dehydrogenase 5a1 gene (succinic semialdehyde dehydrogenase(SSADH)-deficient mice). These animals represent a...

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Vydáno v:Toxicol In Vitro
Hlavní autoři: Vogel, KR, Ainslie, GR, McConnell, A, Roullet, J-B, Gibson, KM
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842807/
https://ncbi.nlm.nih.gov/pubmed/29031482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2017.10.015
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