Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD

BACKGROUND: Smoking represents a significant risk factor for many chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). METHODS: To identify dysregulation of specific proteins and pathways in bronchoalveolar lavage (BAL) cells associated with smoking, isobaric tags f...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Yang, Mingxing, Kohler, Maxie, Heyder, Tina, Forsslund, Helena, Garberg, Hilde K., Karimi, Reza, Grunewald, Johan, Berven, Frode S., Magnus Sköld, C., Wheelock, Åsa M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842534/
https://ncbi.nlm.nih.gov/pubmed/29514648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-017-0695-6
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