Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype

Abstract Background Smoking is the main risk factor for chronic obstructive pulmonary disease (COPD). Women with COPD who smoke experienced a higher risk of hospitalization and worse decline of lung function. Yet the mechanisms of these gender-related differences in clinical presentations in COPD re...

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Hauptverfasser: Mingxing Yang, Maxie Kohler, Tina Heyder, Helena Forsslund, Hilde K. Garberg, Reza Karimi, Johan Grunewald, Frode S. Berven, Sven Nyrén, C. Magnus Sköld, Åsa M. Wheelock
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2018-03-01
Schriftenreihe:Respiratory Research
Schlagworte:
Chronic obstructive pulmonary disease
Bronchoalveolar lavage
Smoking
Gender difference
Proteomics
Isobaric tags for relative and absolute quantitation
Online Zugang:http://link.springer.com/article/10.1186/s12931-017-0699-2
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