Metformin normalizes the structural changes in glycogen preceding prediabetes in mice overexpressing neuropeptide Y in noradrenergic neurons

Hepatic insulin resistance and increased gluconeogenesis are known therapeutic targets of metformin, but the role of hepatic glycogen in the pathogenesis of diabetes is less clear. Mouse model of neuropeptide Y (NPY) overexpression in noradrenergic neurons (OE‐NPY(D) (βH)) with a phenotype of late o...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Ailanen, Liisa, Bezborodkina, Natalia N., Virtanen, Laura, Ruohonen, Suvi T., Malova, Anastasia V., Okovityi, Sergey V., Chistyakova, Elizaveta Y., Savontaus, Eriika
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842371/
https://ncbi.nlm.nih.gov/pubmed/29541475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.389
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