Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis

NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein (TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in inflammation. However, the involvement of this process in tubular damage in the kidneys of patients with diabetic nephropathy (DN) is unclear. He...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Han, Yachun, Xu, Xiaoxuan, Tang, Chengyuan, Gao, Peng, Chen, Xianghui, Xiong, Xiaofen, Yang, Ming, Yang, Shikun, Zhu, Xuejing, Yuan, Shuguang, Liu, Fuyou, Xiao, Li, Kanwar, Yashpal S., Sun, Lin
Format: Artigo
Language:Inglês
Published: Elsevier 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842313/
https://ncbi.nlm.nih.gov/pubmed/29475133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.02.013
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