Two models of inescapable stress increase tph2 mRNA expression in the anxiety-related dorsomedial part of the dorsal raphe nucleus

Expression of TPH2, the rate-limiting enzyme for brain serotonin synthesis, is elevated in the dorsal raphe nucleus (DR) of depressed suicide victims. One hypothesis is that this increase in TPH2 expression is stress-induced. Here, we used an established animal model to address whether exposure to a...

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Detalhes bibliográficos
Publicado no:Neurobiol Stress
Main Authors: Donner, Nina C., Kubala, Kenneth H., Hassell Jr., James E., Lieb, Margaret W., Nguyen, Kadi T., Heinze, Jared D., Drugan, Robert C., Maier, Steven F., Lowry, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842308/
https://ncbi.nlm.nih.gov/pubmed/29520369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ynstr.2018.01.003
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