Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation

Immunomodulatory activity of mesenchymal stem cells (MSCs) is largely mediated by paracrine factors. Our previous studies showed that activation of nuclear factor-kappa B (NF-κB) regulates cytokine/growth factor secretion by MSCs. This study aimed to elucidate the role of Rap1 (repressor/activator p...

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Publicat a:Cell Death Dis
Autors principals: Ding, Yue, Liang, Xiaoting, Zhang, Yuelin, Yi, Li, Shum, Ho Cheung, Chen, Qiulan, Chan, Barbara P., Fan, Huimin, Liu, Zhongmin, Tergaonkar, Vinay, Qi, Zhongquan, Tse, Hung-fat, Lian, Qizhou
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842217/
https://ncbi.nlm.nih.gov/pubmed/29515165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0414-3
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