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Role of A-Kinase Anchoring Protein Phosphorylation in Alcohol-Induced Liver Injury and Hepatic Stellate Cell Activation

Alcoholic liver injury is associated with hepatic stellate cell (HSC) activation. A-kinase anchoring protein 12 (AKAP12) scaffolds protein kinase C and cyclin-D1, which is regulated by its phosphorylation, and spatiotemporally controls cell proliferation, invasiveness, and chemotaxis. HSC activation...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Pathol
Hauptverfasser: Ramani, Komal, Tomasi, Maria Lauda, Berlind, Joshua, Mavila, Nirmala, Sun, Zhaoli
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842034/
https://ncbi.nlm.nih.gov/pubmed/29305319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2017.11.017
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