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Structure basis for directional R-loop formation and substrate handover mechanisms in Type I CRISPR-Cas system
Type I CRISPR systems feature a sequential dsDNA target searching and degradation process, by crRNA-displaying Cascade and nuclease-helicase fusion enzyme Cas3, respectively. Here we present two cryo-EM snapshots of the Thermobifida fusca Type I-E Cascade: 1) unwinding 11-bp of dsDNA at the seed-seq...
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| 發表在: | Cell |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5841471/ https://ncbi.nlm.nih.gov/pubmed/28666122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.06.012 |
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