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The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes
LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of IL-12-family cytokines. IL12/18 promote TH(1)-differentiation, counteracting the TH(2)-driven asthma. Therefore, CD14 modulation could alter the TH(2)-differentiation and should be taken into account when studying asthma....
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5841440/ https://ncbi.nlm.nih.gov/pubmed/29515128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20483-1 |
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