Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?

PURPOSE: Many anticancer drugs induce apoptosis in malignant cells, and resistance to apoptosis could lead to suboptimal or no therapeutic benefit. Two cytoplasmic proteins, B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and Bcl-2, act as a promoter and an inhibitor of apoptosis, respectively....

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Bibliografiska uppgifter
I publikationen:Cancer Manag Res
Huvudupphovsmän: Kulsoom, Bibi, Shamsi, Tahir Sultan, Afsar, Nasir Ali, Memon, Zahida, Ahmed, Nikhat, Hasnain, Syed Nazrul
Materialtyp: Artigo
Språk:Inglês
Publicerad: Dove Medical Press 2018
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841349/
https://ncbi.nlm.nih.gov/pubmed/29535553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S154608
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