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Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression

Cancer stem cells (CSCs) niche in the tumor microenvironment is responsible for cancer recurrence and therapy failure. To better understand its molecular and biological involvement in hepatocellular carcinoma (HCC) progression, one can design more effective therapies and tailored then to individual...

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Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Rani, Bhavna, Malfettone, Andrea, Dituri, Francesco, Soukupova, Jitka, Lupo, Luigi, Mancarella, Serena, Fabregat, Isabel, Giannelli, Gianluigi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841307/
https://ncbi.nlm.nih.gov/pubmed/29515105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0384-5
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