Magnolol restores the activity of meropenem against NDM-1-producing Escherichia coli by inhibiting the activity of metallo-beta-lactamase

The emergence of plasmid-mediated New Delhi metallo-β-lactamase-1 (NDM-1) in carbapenem-resistant Gram-negative pathogens is an increasing clinical threat. Here we report the discovery of an NDM-1 inhibitor, magnolol, through enzyme inhibition screening. We showed that magnolol significantly inhibit...

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Pubblicato in:Cell Death Discov
Autori principali: Liu, Shui, Zhou, Yonglin, Niu, Xiaodi, Wang, Tingting, Li, Jiyun, Liu, Zhongjie, Wang, Jianfeng, Tang, Shusheng, Wang, Yang, Deng, Xuming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841300/
https://ncbi.nlm.nih.gov/pubmed/29531825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-018-0029-6
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