Haploinsufficient TNAP Mice Display Decreased Extracellular ATP Levels and Expression of Pannexin-1 Channels

Hypophosphatasia (HPP) is a rare heritable metabolic bone disease caused by hypomorphic mutations in the ALPL (in human) or Akp2 (in mouse) gene, encoding the tissue-nonspecific alkaline phosphatase (TNAP) enzyme. In addition to skeletal and dental malformations, severe forms of HPP are also charact...

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Publicat a:Front Pharmacol
Autors principals: Sebastián-Serrano, Álvaro, de Diego-García, Laura, Henshall, David C., Engel, Tobías, Díaz-Hernández, Miguel
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841270/
https://ncbi.nlm.nih.gov/pubmed/29551976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00170
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