Tetramethylpyrazine Showed Therapeutic Effects on Sepsis-Induced Acute Lung Injury in Rats by Inhibiting Endoplasmic Reticulum Stress Protein Kinase RNA-Like Endoplasmic Reticulum Kinase (PERK) Signaling-Induced Apoptosis of Pulmonary Microvascular Endothelial Cells

BACKGROUND: Acute lung injury (ALI) is a life-threatening complication of sepsis. Tetramethylpyrazine (TMP) has been used in the clinical treatment of vascular diseases. The aim of this study was to investigate the therapeutic effects and possible involved mechanisms on ALI. MATERIAL/METHODS: Cecal...

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Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Med Sci Monit
Hauptverfasser: Liu, Wensheng, Liu, Kaizhong, Zhang, Shu, Shan, Lihong, Tang, Jiangfeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Scientific Literature, Inc. 2018
Schlagworte:
Lab/In Vitro Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5841188/
https://ncbi.nlm.nih.gov/pubmed/29488473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.908616
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