Knockout of l-Histidine Decarboxylase Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling

Feeding a high-fat diet (HFD) coupled with sugar, mimicking a Western diet, causes fatty liver disease in mice. Histamine induces biliary proliferation and fibrosis and regulates leptin signaling. Wild-type (WT) and l-histidine decarboxylase (Hdc(−/−)) mice were fed a control diet or an HFD coupled...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Kennedy, Lindsey, Hargrove, Laura, Demieville, Jennifer, Bailey, Jennifer M., Dar, Wasim, Polireddy, Kishore, Chen, Qingzheng, Nevah Rubin, Moises I., Sybenga, Amelia, DeMorrow, Sharon, Meng, Fanyin, Stockton, Lindsey, Alpini, Gianfranco, Francis, Heather
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840487/
https://ncbi.nlm.nih.gov/pubmed/29248461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2017.11.016
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