Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma

BACKGROUND: In several tumours the endogenous activity of histidine decarboxylase (HDC), the enzyme stimulating histamine synthesis, sustains the autocrine trophic effect of histamine on cancer progression. Cholangiocarcinoma is a biliary cancer with limited treatment options. Histamine interacts wi...

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Detalhes bibliográficos
Main Authors: Francis, Heather, DeMorrow, Sharon, Venter, Julie, Onori, Paolo, White, Mellanie, Gaudio, Eugenio, Francis, Taylor, Greene, John F, Tran, Steve, Meininger, Cynthia J, Alpini, Gianfranco
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244572/
https://ncbi.nlm.nih.gov/pubmed/21873469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-300007
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