Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition

Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular organisms. Cytochrome c is a central figure in the activation of the apoptotic intrinsic pathway, thereby activating the caspase cascade through its interaction with Apaf-1. O...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Elena-Real, Carlos A., Díaz-Quintana, Antonio, González-Arzola, Katiuska, Velázquez-Campoy, Adrián, Orzáez, Mar, López-Rivas, Abelardo, Gil-Caballero, Sergio, De la Rosa, Miguel Á., Díaz-Moreno, Irene
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840378/
https://ncbi.nlm.nih.gov/pubmed/29511177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0408-1
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