Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced melanoma. The first ICI to demonstrate clinical benefit, ipilimumab, targets cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4); however, the long-term overall survival is just 22%. More than 40 years ago intralesion...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Immunol
Prif Awduron: Da Gama Duarte, Jessica, Parakh, Sagun, Andrews, Miles C., Woods, Katherine, Pasam, Anupama, Tutuka, Candani, Ostrouska, Simone, Blackburn, Jonathan M., Behren, Andreas, Cebon, Jonathan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2018
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840202/
https://ncbi.nlm.nih.gov/pubmed/29552014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00411
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