Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced melanoma. The first ICI to demonstrate clinical benefit, ipilimumab, targets cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4); however, the long-term overall survival is just 22%. More than 40 years ago intralesion...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Da Gama Duarte, Jessica, Parakh, Sagun, Andrews, Miles C., Woods, Katherine, Pasam, Anupama, Tutuka, Candani, Ostrouska, Simone, Blackburn, Jonathan M., Behren, Andreas, Cebon, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840202/
https://ncbi.nlm.nih.gov/pubmed/29552014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00411
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